PIRC at ACOG 2017

Megan Allyse is representing PIRC at the 2017 annual meeting of the American Congress of Obstetrics and Gynecology (ACOG) in San Diego, with a poster presenting preliminary findings from the ERRORS (Errors in Reading and Reporting On Results of Screening) study. She presented the ERRORS poster, titled “Decisional Regret in Women Receiving High-risk or Inconclusive Results from Non-invasive Prenatal Genetic Screening,” in ePoster Session B on Saturday (Poster 24B).

She is also presenting a poster on ethical considerations in uterine transplantation surgery, in ePoster Session P on Tuesday (Poster 30P). Congratulations Megan!

Full program for the ACOG 2017 annual meeting.

See you at #ACMG2016!

ACMG 2016 logo (150x60)-white

We are happy to be well-represented at this year’s national meeting of the American College of Medical Genetics and Genomics (ACMG). Swing by our posters and say hello!

Thursday poster session:
Poster #437
The National Center for Prenatal and Postnatal Resources: Evaluating the progressive annual utilization of a recommended patient education resource two years after the release of the 2013 ACMG statement on noninvasive prenatal screening for fetal aneuploidy
Stephanie Meredith

Poster #479
Inaccurate or Unknown Findings from cfDNA Testing: Experiences of Women and Families
Megan A. Allyse

Friday poster session:
Poster #436
Expanded prenatal cfDNA screening: Genetic counselors’ opinions regarding provider education needs (click here to see poster)
Marsha Michie, Megan A. Allyse, Stephanie A. Kraft, Subhashini Chandrasekharan, and Jessica Mozersky


How do we deal with NIPGS and ‘The Big C’?

Stories have been circulating for a while now that anomalous non-invasive prenatal genetic screening (NIPGS) results may sometimes indicate maternal cancer. Recently, however, these anecdotes have given way to more rigorous data, from a group of researchers at University of Leuven in Belgium, and from US companies Sequenom and Illumina.

Laura Linney in The Big C; photo from http://popculturezoo.com/2010/11/take-a-peek-at-the-weeds-and-the-big-c-season-finales/
Laura Linney in television show “The Big C” (photo from http://popculturezoo.com/2010/11/take-a-peek-at-the-weeds-and-the-big-c-season-finales/)

For many this new discovery is not all that surprising. For several years now, researchers have been pursuing a test, based on cell-free DNA, that would provide a reliable “liquid biopsy.” Indeed, such tests are already being used clinically in limited circumstances, though–as with NIPGS–the rapid translation of this technology has left important questions about reliability and actionability as yet unanswered. Even more promising, sequencing cell-free DNA may circumvent some of the problems recently proposed with sequencing tumor DNA without matched controls from normal tissue–because both kinds of DNA will be present in serum, and can be distinguished by their relative frequency, much as NIPGS does with fetal and maternal cell-free DNA. Continue reading How do we deal with NIPGS and ‘The Big C’?