This study examined understanding of results, clinical follow-up and decisional regret in women who had received a false positive result from a noninvasive cfDNA screening test. PregnantWomanWomen were recruited through online pregnancy forums and interviewed by telephone.

Key Findings:

Women overwhelmingly report that they do not consider they made an informed decision regarding undergoing cfDNA screening. Many felt that if they had known about the potential for a false positive before agreeing to testing they may have made a different testing decision. Alternately, they might have received a high-risk result differently, knowing that the possibility of a false positive existed.

Papers from this study:

Gammon E, Jaramillo C and Allyse M. (Submitted) Decisional Regret in Women Receiving High-Risk or Inconclusive Results from Non-Invasive Prenatal Genetic Screening. Prenatal Diagnosis. 

Presentations from this study:

Decisional Regret in Women Receiving High-Risk or Inconclusive Results from Non-Invasive Prenatal Genetic Screening. 2016. Annual Meeting of the International Society for Prenatal Diagnosis. Berlin, Germany.

The effects of delivery context on women’s experiences of prenatal cfDNA screening: A tale of two studies. 2017. American College of Medical Genetics Annual Clinical Genetics Meeting. Phoenix, AZ. [Download PDF here]